Repatha^® is used:

• along with diet and in combination with usual therapy, including cholesterol-lowering medications called statins, to reduce the risk of heart attack, stroke, and certain heart procedures (to restore blood flow to the heart) in adult patients who have cardiovascular disease by further lowering low-density lipoprotein (LDL) cholesterol.
• along with diet, alone or together with other cholesterol-lowering therapies, in adults with primary hyperlipidemia (high LDL cholesterol level in your blood) to reduce LDL cholesterol.
• along with diet and other cholesterol-lowering therapies, to reduce LDL cholesterol in people 10 years and older who need additional lowering of the high LDL cholesterol in their blood because of a condition that runs in their family (heterozygous familial hypercholesterolemia [HeFH]).
• along with diet and other cholesterol-lowering therapies, to reduce LDL cholesterol in people 10 years and older who need additional lowering of the high LDL cholesterol in their blood because of a condition that runs in their family (homozygous familial hypercholesterolemia [HoFH]).

You should stay on your cholesterol-lowering diet while taking this medicine.

Do not use Repatha^® if you have ever had an allergic reaction to Repatha^® or any of the ingredients in Repatha^®.

Do not use Repatha^® if you are allergic or sensitive to rubber or latex, as the needle cap on the SureClick Autoinjector contains dry natural rubber. There is no dry natural rubber in the automated mini-doser with prefilled cartridge.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take Repatha^®. Talk about any health conditions or problems you may have.

If you use Repatha^® together with a statin and other cholesterol-lowering medicines, please read the package leaflet of that medicine.

Children and adolescents
The use of Repatha^® has been studied in children 10 years of age and older being treated for heterozygous or homozygous familial hypercholesterolemia.

The use of Repatha^® has not been studied in children under 10 years of age or in children with other types of hypercholesterolemia.

Pregnancy and breastfeeding
Repatha^® has not been tested in pregnant women. It is not known if Repatha^® will harm your unborn baby.

• If you are trying to get pregnant or think you may be pregnant when taking Repatha^®, inform your doctor.
• If you are also taking a statin along with Repatha^®, stop taking Repatha^® and read the package leaflet of the statin that you are taking.

It is not known whether Repatha^® is found in breast milk. It is important to tell your doctor if you are breastfeeding or plan to do so. Your doctor will then help you decide whether to stop breastfeeding, or whether to stop taking Repatha^®, considering the benefit of breastfeeding to the baby and the benefit of Repatha^® to the mother.

Women who become pregnant during Repatha^® treatment, or their healthcare provider, are encouraged to call Amgen at 1-866-502-6436 to report the pregnancy.

No important drug interactions have been identified for Repatha^®. No drug-drug interaction studies have been carried out for Repatha^®.

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.